MOLECULAR BIOLOGY OF CANCER-REG 2K6

Code No: RR412305 Set No. 1
IV B.Tech I Semester Regular Examinations, November 2006
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. (a) Describe the various check points operating in animal cells.
(b) Discuss the mechanisms by which the check points control cell cycle progres-
sion. [8+8]
2. How does Ras protein control cell cycle? Majority of C-Ras oncogenes obtained
from cancerous tissue have mutations in codon 12, 13, 59 or 61 in the coding
sequence. Suggest an explanation. [16]
3. Compare and contrast the anti-tumor activity of P53 and Rb gene. [16]
4. Describe Ames Test in detail. Which chemicals are subjected to this test? [16]
5. (a) What are ionizing radiations and what type of damages could they produce
in the DNA molecule? Discuss in detail.
(b) Correlate DNA damage with carcinogenesis. [8+8]
6. (a) List the food components that could be associated with carcinogenic activity.
(b) List the food components that could give protection against carcinogenic ac-
tivity of other compounds. [8+8]
7. Name the different forms of radiographic examinations in diagnosis of tumors of
different types. [16]
8. What different types of damages are expected with radiation therapy and what
response is expected in normal cells and tumor cells to radiation dose?
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Code No: RR412305 Set No. 2
IV B.Tech I Semester Regular Examinations, November 2006
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Write short notes on any 2 of the following:-
(a) TGF-
(b) Family of E2F
(c) MPF
(d) Cyclins. [8+8]
2. (a) What is autocrine induction?
(b) Write the mechanism of autocrine induction of growth factors leading to ma-
lignant transformation in the cell. [8+8]
3. What type of mutation causes proto oncogenes to convert them to oncogenes? Give
one specific example. [16]
4. Discuss the role of different environmental substances as causative agents of cancers
providing some specific examples. [16]
5. What are the 3 types of UV light? Describe in detail the specific mutagenic actions
produced by each and mention their carcinogenic potentials. [16]
6. Detail the characteristic features that differentiate a benign tumor from a malignant
tumor. [16]
7. (a) On what principle does ultrasonography work?
(b) Cancers in which suspected parts of the body are screened by ultasonography?
[8+8]
8. Describe the different types of radiations and their sources that are used in radio-
therapy for the treatment of cancers. Also describe the radiation units that measure
the dose. [16]
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Code No: RR412305 Set No. 3
IV B.Tech I Semester Regular Examinations, November 2006
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Name a signal transducer molecule that functions in normal cell signaling and its
mutated form which induces cancer. [16]
2. Mutations in proto oncogenes that change them to oncogenes are dominant. Pro-
vide a correct explanation with suitable examples. [16]
3. Name the 2 different types of retinoblastomas. Discuss the genetic basis for each.
[16]
4. Bruce Ames in 1984 stated that “We are eating 10,000 times more of natures’
pesticides than man-made pesticides”. Comment on this statement. [16]
5. Write short notes on any 2 of the following:-
(a) UV-A light and the carcinogenic activity
(b) UV-B light and the carcinogenic activity
(c) UV-C light and the carcinogenic activity. [8+8]
6. The American Cancer Society has listed some very common warning signals as
cautions. List these signals. Why is it important to check for these signals? Discuss.
[16]
7. Name the different forms of radiographic examinations in diagnosis of tumors of
different types. [16]
8. Which types of tumors could be subjected to surgical treatment? Mention the
benefits and hazards of the surgical procedure. [16]
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Code No: RR412305 Set No. 4
IV B.Tech I Semester Regular Examinations, November 2006
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Write short notes on any 2 of the following:-
(a) TGF-
(b) Family of E2F
(c) MPF
(d) Cyclins. [8+8]
2. (a) Define transformation of cells.
(b) Describe the changes produced when cells in normal tissue culture are trans-
formed by tumor viruses. [8+8]
3. Which gene involvement is indicated in patient with breast and ovarian carcinomas?
Discuss in detail the mechanism controlling the induction of these cancers. [16]
4. Benzo [a] pyrine is the most well known carcinogen. Which group of chemical
carcinogens produce it and by what mechanism? Name the specific cancers that
show the involvement of this molecule? [16]
5. (a) Name the different units that measure radiation energy.
(b) Describe the rate of release of energy and its biological effects. [8+8]
6. Summarize the steps involved in metastasis. [16]
7. Discuss the usefulness of the Antigen Titre Values in blood tests. Name the antigens
that are tested and their association in the diagnosis and prognosis of specific
cancer. [16]
8. What factors have to be evaluated to make an intelligent plan of the treatment
schedule for the cancer patients? [16]
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