MOLECULAR BIOLOGY OF CANCER-NOV 2K7

Code No: RR412305 Set No. 1
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. (a) Define and differentiate START and Restriction point.
(b) What are the factors and mechanisms controlling passage of cells through
these points? [8+8]
2. Name one proto oncogene that functions in signal transduction pathway controlling
cellular proliferation and its oncogenic protein leading to malignant transformation.
[16]
3. Explain why individuals who develop non-hereditary retinoblastoma usually have
tumors in only one eye where as those with hereditary retinoblastoma usually de-
velop tumors in both eyes. [16]
4. Discuss the molecular basis of cancer induction by chemical carcinogens. [16]
5. Write short notes on any 2 of the following:-
(a) UV-A light and the carcinogenic activity
(b) UV-B light and the carcinogenic activity
(c) UV-C light and the carcinogenic activity. [8+8]
6. The international comparison of clinical staging is standardized in 1959 under
“TNM” system. Explain in detail the method followed in staging the cancer by the
TNM method. [16]
7. What are Microarray assays? How useful are they in tumor diagnosis? Comment.
[16]
8. What is the main purpose of palliation (surgery) and in what type of cancer is it
recommended? [16]
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Code No: RR412305 Set No. 2
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Enumerate in detail the pathway by which Ras protein checks cell cycle progression
in response to environmental factors. [16]
2. (a) Define transformation of cells.
(b) Describe the changes produced when cells in normal tissue culture are trans-
formed by tumor viruses. [8+8]
3. Describe the function of the normal Rb gene in controlling cell cycle progression.
[16]
4. Which chemical carcinogens are involved in the induction of skin cancers? Name
the source of these carcinogens. [16]
5. Discuss on the every day exposure of human population to radiations from nat-
ural and artificial sources and proportions contributed by each. Correlate these
exposures with cancers in the present era. [16]
6. What is invasion and describe the mechanism of invasion. [16]
7. What is the main difference between normal radiographic imaging and Magnetic
Resonance Imaging? Which is superior in diagnosis and why? [16]
8. Provide the importance of discussing the psycho-sociological aspects of the patients
as a pre- treatment preparation. [16]
⋆ ⋆ ⋆ ⋆ ⋆
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Code No: RR412305 Set No. 3
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Write short notes on any 2 of the following:-
(a) TGF-
(b) Family of E2F
(c) MPF
(d) Cyclins. [8+8]
2. (a) Define transformation of cells.
(b) Describe the changes produced when cells in normal tissue culture are trans-
formed by tumor viruses. [8+8]
3. Describe Rb gene locus and the possible mutations that repress the activity of Rb
protein which induces cancer. [16]
4. Which chemical carcinogens are involved in the induction of skin cancers? Name
the source of these carcinogens. [16]
5. What are the 3 types of UV light? Describe in detail the specific mutagenic actions
produced by each and mention their carcinogenic potentials. [16]
6. Summarize the steps involved in metastasis. [16]
7. What is Aspiration biopsy? Describe the technique, its usefulness and the risk
involved. [16]
8. Write short notes on the following: - [4+4+4+4]
(a) Hypoxic cells
(b) Radiation effect on cell cycle
(c) Cell repair
(d) Repopulation following radiation treatment.
⋆ ⋆ ⋆ ⋆ ⋆
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Code No: RR412305 Set No. 4
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆ ⋆ ⋆ ⋆ ⋆
1. Enumerate in detail the pathway by which Ras protein checks cell cycle progression
in response to environmental factors. [16]
2. (a) Define transformation of cells.
(b) Describe the changes produced when cells in normal tissue culture are trans-
formed by tumor viruses. [8+8]
3. What type of mutation causes proto oncogenes to convert them to oncogenes? Give
one specific example. [16]
4. Discuss the different sources of carcinogens that enter our environment and the
proportion contributed by each of these sources towards the development of human
cancers. [16]
5. Write short notes on any 2 of the following:-
(a) UV-A light and the carcinogenic activity
(b) UV-B light and the carcinogenic activity
(c) UV-C light and the carcinogenic activity. [8+8]
6. Environmental factors including diet play a very important role in developing can-
cer. Distinguish the dietary factors associated with carcinogenesis showing the
association of food with a specific cancer. [16]
7. What is the main difference between normal radiographic imaging and Magnetic
Resonance Imaging? Which is superior in diagnosis and why? [16]
8. Provide the importance of discussing the psycho-sociological aspects of the patients
as a pre- treatment preparation. [16]
⋆ ⋆ ⋆ ⋆ ⋆
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